屬性
密度
1.4000
熔點
328.47 °C
沸點
~836.0 °C at 760 mmHg
溶解性
DMSO
存貯條件
儲存溫度-20°C
描述
產品介紹
LY411575是γ-secretase抑制劑，基于膜和細胞的實驗IC50分別為0.078 nM/0.082 nM，還能抑制Notch clevage，IC50為0.39 nM。
別名
LY411575; LY 411575; (aS)-N-[(1S)-2-[[(7S)-6,7-二氫-5-甲基-6-氧代-5H-二苯并[b,d]氮雜卓-7-基]氨基]-1-甲基-2-氧代乙基]-3,5-二氟-alpha-羥基苯乙酰胺;LY411575; LY 411575;(aS)-N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-alpha-hydroxybenzeneacetamide; N2-[(2S)-2-(3,5-Difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide
生化機理
LY-411575 is potent, cell permeable and selective γ-secretase inhibitor that reduces Aβ/42 after acute or chronic treatment, and blocks Notch activation. Studies (Cancer Cell) have shown that treatment with LSN-411575 arrests KrasG12V-driven NSCLCs in association with inhibition of HES1 expression and ERK phosphorylation.
應用
A potent γ-secretase inhibitor